Maija Hirsilä Selected Research

Transcription Factors (Transcription Factor)

7/2010	Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.
8/2005	Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
12/2004	Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.
3/2004	Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

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Maija Hirsilä Research Topics

Disease

8	Hypoxia (Hypoxemia) 07/2010 - 08/2003
1	Neoplasms (Cancer) 02/2007

Drug/Important Bio-Agent (IBA)

6	Oxygen (Dioxygen)IBA 09/2009 - 08/2003
4	Transcription Factors (Transcription Factor)IBA 07/2010 - 03/2004
2	EnzymesIBA 09/2009 - 03/2004
2	Mixed Function Oxygenases (Monooxygenases)IBA 02/2007 - 08/2005
2	Peptides (Polypeptides)IBA 09/2006 - 12/2004
1	CollagenIBA 09/2009
1	Succinic Acid (Succinate)IBA 02/2007
1	FumaratesIBA 02/2007
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 02/2007
1	disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA 09/2006
1	Hypoxia-Inducible Factor-Proline DioxygenasesIBA 12/2004
1	leucyl-alanineIBA 12/2004
1	Azetidinecarboxylic AcidIBA 12/2004
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 12/2004
1	Proline (L-Proline)FDA Link 12/2004
1	3,4-dehydroprolineIBA 12/2004